IMMUNOMET: EU Working Group on ImmunoMetabolism

Yearly Archives: 2017

Team of G Matarese: De Rosa V et al. 2017. Nat Immunol 18:1190. (LINK). Abstract The prevalence of autoimmune disorders in affluent countries has reached epidemic proportions. Over the past 50 years, a reverse trend between the frequency of infectious diseases and the incidence of autoimmune and allergic diseases led […]

Metabolic pressure and the breach of immunological self-tolerance

This entry was posted in Consortium Articles on October 27, 2017

Team of M Netea: Netea MG et al. 2017. Nat Immunol 18:826. (LINK). Abstract Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to […]

A guiding map for inflammation

This entry was posted in Consortium Articles on August 29, 2017

Team of G Eberl: Stzepourginski I et al. 2017. Proc Natl Acad Sci U S A 114:E506. (LINK). Abstract The intestinal epithelium is continuously renewed by intestinal epithelial stem cells (IESCs) positioned at the base of each crypt. Mesenchymal-derived factors are essential to maintain IESCs; however, the cellular composition and development […]

CD34+ mesenchymal cells are a major component of the intestinal ...

This entry was posted in Consortium Articles on August 29, 2017

Team of L O’Neil: Mills EL et al. 2017. Nat Immunol 18:488. (LINK). Abstract Recent evidence indicates that mitochondria lie at the heart of immunity. Mitochondrial DNA acts as a danger-associated molecular pattern (DAMP), and the mitochondrial outer membrane is a platform for signaling molecules such as MAVS in RIG-I signaling, […]

Mitochondria are the powerhouses of immunity

This entry was posted in Consortium Articles on August 29, 2017

Team of T Chavakis: Chung KJ et al. 2017. Nat Immunol 18:654. (LINK). Abstract In obesity, inflammation of white adipose tissue (AT) is associated with diminished generation of beige adipocytes (‘beige adipogenesis’), a thermogenic and energy-dissipating function mediated by beige adipocytes that express the uncoupling protein UCP1. Here we delineated an […]

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in ...

This entry was posted in Consortium Articles on August 29, 2017