Daily Archives: June 10, 2015

Team of T Chavakis: Chung KJ et al. 2014. Mol Biol Cell 25:2948. (LINK). Abstract Rapid beta2-integrin activation is indispensable for leukocyte adhesion and recruitment to sites of infection and is mediated by chemokine- or P-selectin glycoprotein ligand-1-induced inside-out signaling. Here we uncovered a novel pathway for rapid activation of integrin-dependent […]

A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte ...

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Team of T Chavakis: Choi EY et al. 2014. Mol Psychiatry. (LINK). Abstract Inflammation in the central nervous system (CNS) and disruption of its immune privilege are major contributors to the pathogenesis of multiple sclerosis (MS) and of its rodent counterpart, experimental autoimmune encephalomyelitis (EAE). We have previously identified developmental endothelial […]

Developmental endothelial locus-1 is a homeostatic factor in the central ...

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Team of T Chavakis: Pruenster M et al. 2015. Nat Commun 6:6915. (LINK). Abstract Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8/14 is unclear. Our present study identifies extracellular MRP8/14 as an autocrine player in […]

Extracellular MRP8/14 is a regulator of beta2 integrin-dependent neutrophil slow ...

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