IMMUNOMET: EU Working Group on ImmunoMetabolism

Monthly Archives: June 2015

Team of T Chavakis: Chatzigeorgiou A et al. 2014. Proc Natl Acad Sci U S A 111:2686. (LINK). Abstract The immune system plays an instrumental role in obesity and insulin resistance. Here, we unravel the role of the costimulatory molecule CD40 and its signaling intermediates, TNF receptor-associated factors (TRAFs), in diet-induced […]

Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin ...

This entry was posted in Consortium Articles on June 11, 2015

Team of T Chavakis: Chatzigeorgiou A et al. 2014. Hepatology 60:1196. (LINK). Abstract The low-grade inflammatory state present in obesity contributes to obesity-related metabolic dysregulation, including nonalcoholic steatohepatitis (NASH) and insulin resistance. Intercellular interactions between immune cells or between immune cells and hepatic parenchymal cells contribute to the exacerbation of liver […]

Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and ...

This entry was posted in Consortium Articles on June 11, 2015

Team of T Chavakis: Chung KJ et al. 2014. Mol Biol Cell 25:2948. (LINK). Abstract Rapid beta2-integrin activation is indispensable for leukocyte adhesion and recruitment to sites of infection and is mediated by chemokine- or P-selectin glycoprotein ligand-1-induced inside-out signaling. Here we uncovered a novel pathway for rapid activation of integrin-dependent […]

A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte ...

This entry was posted in Consortium Articles on June 10, 2015

Team of T Chavakis: Choi EY et al. 2014. Mol Psychiatry. (LINK). Abstract Inflammation in the central nervous system (CNS) and disruption of its immune privilege are major contributors to the pathogenesis of multiple sclerosis (MS) and of its rodent counterpart, experimental autoimmune encephalomyelitis (EAE). We have previously identified developmental endothelial […]

Developmental endothelial locus-1 is a homeostatic factor in the central ...

This entry was posted in Consortium Articles on June 10, 2015

Team of T Chavakis: Pruenster M et al. 2015. Nat Commun 6:6915. (LINK). Abstract Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8/14 is unclear. Our present study identifies extracellular MRP8/14 as an autocrine player in […]

Extracellular MRP8/14 is a regulator of beta2 integrin-dependent neutrophil slow ...

This entry was posted in Consortium Articles on June 10, 2015

Team of T Chavakis: Weber GF et al. 2015. Science 347:1260. (LINK). Abstract Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host reaction to microbial infection. Despite the prevalence and severity of sepsis, we lack a fundamental grasp of its pathophysiology. Here we report that the cytokine […]

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target ...

This entry was posted in Consortium Articles on June 10, 2015