Daily Archives: March 13, 2015


Team of T Chavakis: Madhusudhan T et al. 2015. Nature communications 6:6496 (LINK). Abstract Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor […]

Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress ...