IMMUNOMET: EU Working Group on ImmunoMetabolism

Daily Archives: March 7, 2015

Team of M Netea: Tunjungputri RN et al. 2015. Thromb Haemost 113 (LINK). Abstract Platelets and platelet-monocyte interaction play an important role in inflammation. Both pro- and anti-inflammatory effects of platelet inhibition have been reported in animal models. This study aimed to investigate the effect of platelets and platelet inhibition […]

Differential effects of platelets and platelet inhibition by ticagrelor on ...

This entry was posted in Consortium Articles on March 7, 2015

Team of T Chavakis: Moutsopoulos NM et al. 2014. Sci Transl Med 6:229ra40 (LINK). Abstract Leukocyte adhesion deficiency type I (LAD-I), a disease syndrome associated with frequent microbial infections, is caused by mutations on the CD18 subunit of beta(2) integrins. LAD-I is invariably associated with severe periodontal bone loss, which […]

Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease ...

This entry was posted in Consortium Articles on March 7, 2015

Team of G Eberl: Eberl G et al. 2015. Nat Immunol 16:1 (LINK). Abstract Researchers gathered in Paris at the first European Molecular Biology Organization conference devoted to innate lymphoid cells and discussed recent advances to further understanding of the development, regulation and function of these intriguing cells.

The brave new world of innate lymphoid cells

This entry was posted in Consortium Articles on March 7, 2015

Team of G Caligiuri: Clement M et al. 2014. Proc Natl Acad Sci U S A 111:E1101 (LINK). Abstract CD31 is a transhomophilic tyrosine-based inhibitory motif receptor and is expressed by both dendritic cells (DCs) and T lymphocytes. Previous studies have established that the engagement of CD31 drives immune-inhibitory signaling […]

CD31 is a key coinhibitory receptor in the development of ...

This entry was posted in Consortium Articles on March 7, 2015

Team of G Matarese: Procaccini C et al. 2014. Frontiers in immunology 5:143 (LINK). Asbtract The nervous and immune systems have long been considered as compartments that perform separate and different functions. However, recent clinical, epidemiological, and experimental data have suggested that the pathogenesis of several immune-mediated disorders, such as […]

Neuro-endocrine networks controlling immune system in health and disease

This entry was posted in Consortium Articles on March 7, 2015

Team of GD Norata: Demetz E et al. 2014. Cell Metab 20:787 (LINK). Abstract Cholesterol metabolism is closely interrelated with cardiovascular disease in humans. Dietary supplementation with omega-6 polyunsaturated fatty acids including arachidonic acid (AA) was shown to favorably affect plasma LDL-C and HDL-C. However, the underlying mechanisms are poorly […]

The arachidonic acid metabolome serves as a conserved regulator of ...

This entry was posted in Consortium Articles on March 7, 2015

Team of A Nicoletti: Clement M et al. 2015. Circulation 131:560 (LINK). Abstract BACKGROUND: -The atheromodulating activity of B cells during the development of atherosclerosis is well documented, but the mechanisms by which these cells are regulated have not been investigated. METHODS AND RESULTS: -Here, we analyzed the contribution of […]

Control of the Tfh-GC B Cell Axis by CD8+ Tregs ...

This entry was posted in Consortium Articles on March 7, 2015

Team of Marelli-Berg: Fu H et al. 2014. Nature communications 5:3436 (LINK). Abstract Localization of CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells to lymphoid and non-lymphoid tissue is instrumental for the effective control of immune responses. Compared with conventional T cells, Treg cells constitute a minute fraction of the T-cell repertoire. Despite this […]

Self-recognition of the endothelium enables regulatory T-cell trafficking and defines ...

This entry was posted in Consortium Articles on March 7, 2015