Monthly Archives: March 2015

Team of T Chavakis: Madhusudhan T et al. 2015. Nature communications 6:6496 (LINK). Abstract Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor […]

Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress ...

Team of G Eberl: Eberl G et al. 2015. Nat Immunol 16:1 (LINK). Abstract Researchers gathered in Paris at the first European Molecular Biology Organization conference devoted to innate lymphoid cells and discussed recent advances to further understanding of the development, regulation and function of these intriguing cells.

The brave new world of innate lymphoid cells

Team of G Matarese: Procaccini C et al. 2014. Frontiers in immunology 5:143 (LINK). Asbtract The nervous and immune systems have long been considered as compartments that perform separate and different functions. However, recent clinical, epidemiological, and experimental data have suggested that the pathogenesis of several immune-mediated disorders, such as […]

Neuro-endocrine networks controlling immune system in health and disease

Team of A Nicoletti: Clement M et al. 2015. Circulation 131:560 (LINK). Abstract BACKGROUND: -The atheromodulating activity of B cells during the development of atherosclerosis is well documented, but the mechanisms by which these cells are regulated have not been investigated. METHODS AND RESULTS: -Here, we analyzed the contribution of […]

Control of the Tfh-GC B Cell Axis by CD8+ Tregs ...

Team of Marelli-Berg: Fu H et al. 2014. Nature communications 5:3436 (LINK). Abstract Localization of CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells to lymphoid and non-lymphoid tissue is instrumental for the effective control of immune responses. Compared with conventional T cells, Treg cells constitute a minute fraction of the T-cell repertoire. Despite this […]

Self-recognition of the endothelium enables regulatory T-cell trafficking and defines ...