IMMUNOMET: EU Working Group on ImmunoMetabolism

Consortium Articles

Team of G Matarese: De Rosa V et al. 2017. Nat Immunol 18:1190. (LINK). Abstract The prevalence of autoimmune disorders in affluent countries has reached epidemic proportions. Over the past 50 years, a reverse trend between the frequency of infectious diseases and the incidence of autoimmune and allergic diseases led […]

Metabolic pressure and the breach of immunological self-tolerance

This entry was posted in Consortium Articles on October 27, 2017

Team of M Netea: Netea MG et al. 2017. Nat Immunol 18:826. (LINK). Abstract Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to […]

A guiding map for inflammation

This entry was posted in Consortium Articles on August 29, 2017

Team of G Eberl: Stzepourginski I et al. 2017. Proc Natl Acad Sci U S A 114:E506. (LINK). Abstract The intestinal epithelium is continuously renewed by intestinal epithelial stem cells (IESCs) positioned at the base of each crypt. Mesenchymal-derived factors are essential to maintain IESCs; however, the cellular composition and development […]

CD34+ mesenchymal cells are a major component of the intestinal ...

This entry was posted in Consortium Articles on August 29, 2017

Team of L O’Neil: Mills EL et al. 2017. Nat Immunol 18:488. (LINK). Abstract Recent evidence indicates that mitochondria lie at the heart of immunity. Mitochondrial DNA acts as a danger-associated molecular pattern (DAMP), and the mitochondrial outer membrane is a platform for signaling molecules such as MAVS in RIG-I signaling, […]

Mitochondria are the powerhouses of immunity

This entry was posted in Consortium Articles on August 29, 2017

Team of T Chavakis: Chung KJ et al. 2017. Nat Immunol 18:654. (LINK). Abstract In obesity, inflammation of white adipose tissue (AT) is associated with diminished generation of beige adipocytes (‘beige adipogenesis’), a thermogenic and energy-dissipating function mediated by beige adipocytes that express the uncoupling protein UCP1. Here we delineated an […]

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in ...

This entry was posted in Consortium Articles on August 29, 2017

Team of M Netea: Cheng S.C et al. 2016. Nature Immunol 17:406. (LINK). Abstract The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages in some patients, immunoparalysis may be encountered, which is associated with a poor outcome. By transcriptional and metabolic profiling of human patients with sepsis, […]

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis ...

This entry was posted in Consortium Articles on April 1, 2016

Immunomet consortium: Norata D et al. 2015. Immunity 43:421. (LINK). Abstract The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions. Immune cell metabolism has therefore become an attractive […]

The Cellular and Molecular Basis of Translational Immunometabolism

This entry was posted in Consortium Articles on September 28, 2015

Team of T Chavakis: Chatzigeorgiou A et al. 2014. Proc Natl Acad Sci U S A 111:2686. (LINK). Abstract The immune system plays an instrumental role in obesity and insulin resistance. Here, we unravel the role of the costimulatory molecule CD40 and its signaling intermediates, TNF receptor-associated factors (TRAFs), in diet-induced […]

Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin ...

This entry was posted in Consortium Articles on June 11, 2015

Team of T Chavakis: Chatzigeorgiou A et al. 2014. Hepatology 60:1196. (LINK). Abstract The low-grade inflammatory state present in obesity contributes to obesity-related metabolic dysregulation, including nonalcoholic steatohepatitis (NASH) and insulin resistance. Intercellular interactions between immune cells or between immune cells and hepatic parenchymal cells contribute to the exacerbation of liver […]

Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and ...

This entry was posted in Consortium Articles on June 11, 2015

Team of T Chavakis: Chung KJ et al. 2014. Mol Biol Cell 25:2948. (LINK). Abstract Rapid beta2-integrin activation is indispensable for leukocyte adhesion and recruitment to sites of infection and is mediated by chemokine- or P-selectin glycoprotein ligand-1-induced inside-out signaling. Here we uncovered a novel pathway for rapid activation of integrin-dependent […]

A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte ...

This entry was posted in Consortium Articles on June 10, 2015