Consortium Articles


Team of M Netea: Netea MG et al. 2017. Nat Immunol 18:826. (LINK). Abstract Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to […]

A guiding map for inflammation



Team of L O’Neil: Mills EL et al. 2017. Nat Immunol 18:488. (LINK). Abstract Recent evidence indicates that mitochondria lie at the heart of immunity. Mitochondrial DNA acts as a danger-associated molecular pattern (DAMP), and the mitochondrial outer membrane is a platform for signaling molecules such as MAVS in RIG-I signaling, […]

Mitochondria are the powerhouses of immunity



Team of T Chavakis: Chung KJ et al. 2017. Nat Immunol 18:654. (LINK). Abstract In obesity, inflammation of white adipose tissue (AT) is associated with diminished generation of beige adipocytes (‘beige adipogenesis’), a thermogenic and energy-dissipating function mediated by beige adipocytes that express the uncoupling protein UCP1. Here we delineated an […]

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in ...



Immunomet consortium: Norata D et al. 2015. Immunity 43:421. (LINK). Abstract The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions. Immune cell metabolism has therefore become an attractive […]

The Cellular and Molecular Basis of Translational Immunometabolism




Team of T Chavakis: Chatzigeorgiou A et al. 2014. Hepatology 60:1196. (LINK). Abstract The low-grade inflammatory state present in obesity contributes to obesity-related metabolic dysregulation, including nonalcoholic steatohepatitis (NASH) and insulin resistance. Intercellular interactions between immune cells or between immune cells and hepatic parenchymal cells contribute to the exacerbation of liver […]

Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and ...


Team of T Chavakis: Chung KJ et al. 2014. Mol Biol Cell 25:2948. (LINK). Abstract Rapid beta2-integrin activation is indispensable for leukocyte adhesion and recruitment to sites of infection and is mediated by chemokine- or P-selectin glycoprotein ligand-1-induced inside-out signaling. Here we uncovered a novel pathway for rapid activation of integrin-dependent […]

A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte ...



Team of T Chavakis: Choi EY et al. 2014. Mol Psychiatry. (LINK). Abstract Inflammation in the central nervous system (CNS) and disruption of its immune privilege are major contributors to the pathogenesis of multiple sclerosis (MS) and of its rodent counterpart, experimental autoimmune encephalomyelitis (EAE). We have previously identified developmental endothelial […]

Developmental endothelial locus-1 is a homeostatic factor in the central ...