IMMUNOMET: EU Working Group on ImmunoMetabolism

Antonino Nicoletti

Team of T Chavakis: Choi EY et al. 2014. Mol Psychiatry. (LINK). Abstract Inflammation in the central nervous system (CNS) and disruption of its immune privilege are major contributors to the pathogenesis of multiple sclerosis (MS) and of its rodent counterpart, experimental autoimmune encephalomyelitis (EAE). We have previously identified developmental endothelial […]

Developmental endothelial locus-1 is a homeostatic factor in the central ...

This entry was posted in Consortium Articles on June 10, 2015

Team of T Chavakis: Pruenster M et al. 2015. Nat Commun 6:6915. (LINK). Abstract Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8/14 is unclear. Our present study identifies extracellular MRP8/14 as an autocrine player in […]

Extracellular MRP8/14 is a regulator of beta2 integrin-dependent neutrophil slow ...

This entry was posted in Consortium Articles on June 10, 2015

Team of T Chavakis: Weber GF et al. 2015. Science 347:1260. (LINK). Abstract Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host reaction to microbial infection. Despite the prevalence and severity of sepsis, we lack a fundamental grasp of its pathophysiology. Here we report that the cytokine […]

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target ...

This entry was posted in Consortium Articles on June 10, 2015

Team of T Chavakis: Madhusudhan T et al. 2015. Nature communications 6:6496 (LINK). Abstract Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor […]

Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress ...

This entry was posted in Consortium Articles on March 13, 2015

Team of M Netea: Tunjungputri RN et al. 2015. Thromb Haemost 113 (LINK). Abstract Platelets and platelet-monocyte interaction play an important role in inflammation. Both pro- and anti-inflammatory effects of platelet inhibition have been reported in animal models. This study aimed to investigate the effect of platelets and platelet inhibition […]

Differential effects of platelets and platelet inhibition by ticagrelor on ...

This entry was posted in Consortium Articles on March 7, 2015

Team of T Chavakis: Moutsopoulos NM et al. 2014. Sci Transl Med 6:229ra40 (LINK). Abstract Leukocyte adhesion deficiency type I (LAD-I), a disease syndrome associated with frequent microbial infections, is caused by mutations on the CD18 subunit of beta(2) integrins. LAD-I is invariably associated with severe periodontal bone loss, which […]

Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease ...

This entry was posted in Consortium Articles on March 7, 2015

Team of G Eberl: Eberl G et al. 2015. Nat Immunol 16:1 (LINK). Abstract Researchers gathered in Paris at the first European Molecular Biology Organization conference devoted to innate lymphoid cells and discussed recent advances to further understanding of the development, regulation and function of these intriguing cells.

The brave new world of innate lymphoid cells

This entry was posted in Consortium Articles on March 7, 2015

Team of G Caligiuri: Clement M et al. 2014. Proc Natl Acad Sci U S A 111:E1101 (LINK). Abstract CD31 is a transhomophilic tyrosine-based inhibitory motif receptor and is expressed by both dendritic cells (DCs) and T lymphocytes. Previous studies have established that the engagement of CD31 drives immune-inhibitory signaling […]

CD31 is a key coinhibitory receptor in the development of ...

This entry was posted in Consortium Articles on March 7, 2015

Team of G Matarese: Procaccini C et al. 2014. Frontiers in immunology 5:143 (LINK). Asbtract The nervous and immune systems have long been considered as compartments that perform separate and different functions. However, recent clinical, epidemiological, and experimental data have suggested that the pathogenesis of several immune-mediated disorders, such as […]

Neuro-endocrine networks controlling immune system in health and disease

This entry was posted in Consortium Articles on March 7, 2015

Team of GD Norata: Demetz E et al. 2014. Cell Metab 20:787 (LINK). Abstract Cholesterol metabolism is closely interrelated with cardiovascular disease in humans. Dietary supplementation with omega-6 polyunsaturated fatty acids including arachidonic acid (AA) was shown to favorably affect plasma LDL-C and HDL-C. However, the underlying mechanisms are poorly […]

The arachidonic acid metabolome serves as a conserved regulator of ...

This entry was posted in Consortium Articles on March 7, 2015