Boss


Team of T Chavakis: Choi EY et al. 2014. Mol Psychiatry. (LINK). Abstract Inflammation in the central nervous system (CNS) and disruption of its immune privilege are major contributors to the pathogenesis of multiple sclerosis (MS) and of its rodent counterpart, experimental autoimmune encephalomyelitis (EAE). We have previously identified developmental endothelial […]

Developmental endothelial locus-1 is a homeostatic factor in the central ...


Team of T Chavakis: Pruenster M et al. 2015. Nat Commun 6:6915. (LINK). Abstract Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8/14 is unclear. Our present study identifies extracellular MRP8/14 as an autocrine player in […]

Extracellular MRP8/14 is a regulator of beta2 integrin-dependent neutrophil slow ...




Team of T Chavakis: Madhusudhan T et al. 2015. Nature communications 6:6496 (LINK). Abstract Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor […]

Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress ...





Team of G Eberl: Eberl G et al. 2015. Nat Immunol 16:1 (LINK). Abstract Researchers gathered in Paris at the first European Molecular Biology Organization conference devoted to innate lymphoid cells and discussed recent advances to further understanding of the development, regulation and function of these intriguing cells.

The brave new world of innate lymphoid cells



Team of G Matarese: Procaccini C et al. 2014. Frontiers in immunology 5:143 (LINK). Asbtract The nervous and immune systems have long been considered as compartments that perform separate and different functions. However, recent clinical, epidemiological, and experimental data have suggested that the pathogenesis of several immune-mediated disorders, such as […]

Neuro-endocrine networks controlling immune system in health and disease